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Journal article

Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism

Abstract:

Objective Parkinson’s disease is characterised neuropathologically by α-synuclein aggregation. Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson’s from atypical parkinsonian syndromes. We assessed the clinical utility of serum neuronal exosomes as biomarkers across the spectrum of Parkinson’s disease, multiple system atrophy and other proteinopathies.

Methods We performed a cross-sectional study of 664 s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/jnnp-2019-322588

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Inorganic Chemistry
Role:
Author
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Name:
Weston Brain Institute
Grant:
WBI
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Name:
Wellcome Trust
Grant:
097479/Z/11/A
More from this funder
Name:
Engineering & Physical Sciences Research Council
Grant:
EP/M006204/1
Publisher:
BMJ Publishing Group
Journal:
Journal of Neurology, Neurosurgery and Psychiatry More from this journal
Volume:
91
Issue:
7
Pages:
720-729
Publication date:
2020-04-09
Acceptance date:
2020-03-23
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
Language:
English
Keywords:
Pubs id:
1096042
Local pid:
pubs:1096042
Deposit date:
2020-03-23

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