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Journal article

Efficacy and tolerability of evolocumab vs ezetimibe in patients with muscle-related statin intolerance: the GAUSS-3 randomized clinical trial

Abstract:

Importance: Muscle-related statin intolerance is reported by 5% to 20% of patients.
Objective: To identify patients with muscle symptoms confirmed by statin rechallenge and compare lipid-lowering efficacy for 2 nonstatin therapies, ezetimibe and evolocumab.
Design, Setting, and Participants: Two-stage randomized clinical trial including 511 adult patients with uncontrolled low-density lipoprotein cholesterol (LDL-C) levels and history of intolerance to 2 or more statins enrolled...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1001/jama.2016.3608

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
Publisher:
American Medical Association
Journal:
Journal of the American Medical Association More from this journal
Publication date:
2016-04-03
Acceptance date:
2016-03-10
DOI:
EISSN:
1538-3598
ISSN:
0098-7484
Pubs id:
pubs:613098
UUID:
uuid:ad982cc6-9b19-48b1-bdd1-9ea7a2d3aa49
Local pid:
pubs:613098
Source identifiers:
613098
Deposit date:
2016-04-04

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