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Degraded collagenase deteriorates islet viability.

Abstract:

OBJECTIVE: The utilization of purified enzyme blends consisting of collagenase class I (CI) and II (CII) and neutral protease is an essential step for clinical islet isolation. Previous studies suggested that the use of enzyme lots containing degraded CI reduced islet release from human pancreata. The present study sought to assess the effect of degraded collagenase on islet function in vitro and posttransplantation. MATERIALS AND METHODS: Crude collagenase was chromatographically separated ...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Transplantation proceedings More from this journal
Volume:
40
Issue:
2
Pages:
370-371
Publication date:
2008-03-01
DOI:
EISSN:
1873-2623
ISSN:
0041-1345
Language:
English
Keywords:
Pubs id:
pubs:272289
UUID:
uuid:ad7eca0a-6bec-444c-bafa-e12ed8caf408
Local pid:
pubs:272289
Source identifiers:
272289
Deposit date:
2012-12-19

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