Journal article
Integrated neural dynamics for behavioral decisions and attentional competition in the prefrontal cortex
- Abstract:
- In the behaving monkey, complex neural dynamics in the prefrontal cortex contribute to context-dependent decisions and attentional competition. We used demixed principal component analysis to track prefrontal activity dynamics in a cued target detection task. In this task, the animal combined identity of a visual object with a prior instruction cue to determine a target/nontarget decision. From population activity, we extracted principal components for each task feature, and examined their time course and sensitivity to stimulus and task variations. For displays containing a single choice object in left or right hemifield, object identity, cue identity and decision were all encoded in population activity, with different dynamics and lateralization. Object information peaked at 100-200 ms from display onset and was largely confined to the contralateral hemisphere. Cue information was weaker, and present even prior to display onset. Integrating information from cue and object, decision information arose more slowly, and was bilateral. Individual neurons contributed independently to coding of the three task features. The analysis was then extended to displays with a target in one hemifield and a competing distractor in the other. In this case, the data suggest that each hemisphere initially encoded the identity of the contralateral object. The distractor representation was then rapidly suppressed, with the final target decision again encoded bilaterally. The results show how information is coded along task-related dimensions while competition is resolved and suggest how information flows within and across frontal lobes to implement a learned behavioral decision.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.7MB, Terms of use)
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- Publisher copy:
- 10.1111/ejn.15757
Authors
- Publisher:
- Wiley
- Journal:
- European Journal of Neuroscience More from this journal
- Volume:
- 56
- Issue:
- 4
- Pages:
- 4393-4410
- Publication date:
- 2022-07-19
- Acceptance date:
- 2022-07-01
- DOI:
- EISSN:
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1460-9568
- ISSN:
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0953-816X
- Language:
-
English
- Keywords:
- Pubs id:
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1267121
- Local pid:
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pubs:1267121
- Deposit date:
-
2022-07-11
Terms of use
- Copyright holder:
- Erez et al
- Copyright date:
- 2022
- Rights statement:
- © 2022 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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