Journal article icon

Journal article

RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction.

Abstract:

The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL fusion proteins have distinct leukemic phenotypes even when expressed in the same cell type, but how this distinction is delineated on a molecular level is poorly understood. Here, we highlight a unique molecular mechanism whereby t...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Cell reports
Volume:
3
Issue:
1
Pages:
116-127
Publication date:
2013-01-05
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
URN:
uuid:ad651e9c-c9f0-4780-abf9-00a909ff8b16
Source identifiers:
375838
Local pid:
pubs:375838

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP