Journal article

Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial

Abstract:: Background: Prostate cancer diagnosis requires biopsy, traditionally performed under local anaesthetic with ultrasound guidance via a transrectal approach (TRUS). Local anaesthetic ultrasound-guided transperineal biopsy (LATP) is gaining popularity in this setting; however, there is uncertainty regarding prostate sampling, infection rates, tolerability, side-effects, and cost-effectiveness. TRANSLATE was a randomised clinical trial that aimed to compare detection of Gleason G... Expand abstract
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Bryant, R. J., Marian, I. R., Williams, R., Lopez, J. F., Mercader, C., Raslan, M., Berridge, C., Whitburn, J., Campbell, T., Tuck, S., Barber, V. S., Scaife, J., Hewitt, A., Taylor, A., Ooms, A., Landeiro, F., Little, M., Wolstenholme, J., Ghosh, S., … Lamb, A. D. (2025). Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial. Lancet Oncology, 26(5), 583–595.

MLA Style

Bryant, RJ, et al. “Local Anaesthetic Transperineal Biopsy versus Transrectal Prostate Biopsy in Prostate Cancer Detection (TRANSLATE): a Multicentre, Randomised, Controlled Trial.” Lancet Oncology, vol. 26, no. 5, 2025, pp. 583–95.

Chicago Style

Bryant, RJ, IR Marian, R Williams, et al. 2025. “Local Anaesthetic Transperineal Biopsy versus Transrectal Prostate Biopsy in Prostate Cancer Detection (TRANSLATE): a Multicentre, Randomised, Controlled Trial.” Lancet Oncology 26 (5): 583–95.
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Files:: Bryant_et_al_2025_Local_anaesthetic_transperineal.pdf

(Preview, Version of record, pdf, 573.6KB, Terms of use)

Publisher copy:: 10.1016/s1470-2045(25)00100-7

Authors

+ Bryant, RJ More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Surgical Sciences
Oxford college:: St Anne's College
Role:: Author
ORCID:: 0000-0002-8330-9251

+ Marian, IR More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Botnar Institute for Musculoskeletal Sciences
Role:: Author
ORCID:: 0000-0002-0692-8112

+ Williams, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Surgical Sciences
Role:: Author

+ Lopez, JF More by this author

Role:: Author

+ Mercader, C More by this author

Role:: Author

More authors...

Contributors

+ TRANSLATE Trial Study Group

Role:: Contributor

+ NIHR Evaluation Trials and Studies Coordinating Centre More from this funder

Grant:: NIHR131233

+ Institute of Cancer Research More from this funder

Funder identifier:: https://ror.org/00dpztj76

Publisher:: Elsevier
Journal:: Lancet Oncology More from this journal
Volume:: 26
Issue:: 5
Pages:: 583-595
Place of publication:: England
Publication date:: 2025-03-21
Acceptance date:: 2025-02-20
DOI:: 10.1016/s1470-2045(25)00100-7
EISSN:: 1474-5488
ISSN:: 1470-2045
Pmid:: 40139210

Language:: English
Keywords:: TRANSLATE Trial Study Group
Pubs id:: 2100974
Local pid:: pubs:2100974
Deposit date:: 2025-04-09
ARK identifier:: ark:/29072/ora_ad3a9bf8638f4fefb488acc80aae407c

Terms of use

Copyright holder:: Bryant et al
Copyright date:: 2025
Rights statement:: © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Licence:: CC Attribution (CC BY)

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