Journal article
PENICILLIN BIOSYNTHESIS - DEPENDENCE OF SUBSTRATE STEREOCHEMISTRY ON THE MODE OF 2ND RING-CLOSURE
- Abstract:
- The stereochemical requirements for the conversion of tripeptides with unsaturated amino acids in the C-terminal position to bicyclic β-lactam products using isopenicillin N synthase was investigated using diastereomeric peptides containing 2R,3S-2-amino-3-methylpent-4-enoic acid and 2R,2R-2-amino-3-methylpent-4-enoic acid.1 1 This work has been published in a preliminary form: J.E. Baldwin, R.M. Adlington, C.J. Schofield, and H.-H Ting, J. Chem. Soc., Chem. Commun., 1989, 758. © 1990.
- Publication status:
- Published
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Authors
- Journal:
- TETRAHEDRON More from this journal
- Volume:
- 46
- Issue:
- 17
- Pages:
- 6145-6154
- Publication date:
- 1990-01-01
- DOI:
- ISSN:
-
0040-4020
- Language:
-
English
- Pubs id:
-
pubs:43486
- UUID:
-
uuid:ad3a1f8e-276b-4400-8598-6923601e3f31
- Local pid:
-
pubs:43486
- Source identifiers:
-
43486
- Deposit date:
-
2012-12-19
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- Copyright date:
- 1990
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