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PENICILLIN BIOSYNTHESIS - DEPENDENCE OF SUBSTRATE STEREOCHEMISTRY ON THE MODE OF 2ND RING-CLOSURE

Abstract:
The stereochemical requirements for the conversion of tripeptides with unsaturated amino acids in the C-terminal position to bicyclic β-lactam products using isopenicillin N synthase was investigated using diastereomeric peptides containing 2R,3S-2-amino-3-methylpent-4-enoic acid and 2R,2R-2-amino-3-methylpent-4-enoic acid.1 1 This work has been published in a preliminary form: J.E. Baldwin, R.M. Adlington, C.J. Schofield, and H.-H Ting, J. Chem. Soc., Chem. Commun., 1989, 758. © 1990.
Publication status:
Published

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Journal:
TETRAHEDRON More from this journal
Volume:
46
Issue:
17
Pages:
6145-6154
Publication date:
1990-01-01
DOI:
ISSN:
0040-4020
Language:
English
Pubs id:
pubs:43486
UUID:
uuid:ad3a1f8e-276b-4400-8598-6923601e3f31
Local pid:
pubs:43486
Source identifiers:
43486
Deposit date:
2012-12-19

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