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Structural basis of vesicle formation at the inner nuclear membrane

Abstract:

Vesicular nucleo-cytoplasmic transport is becoming recognized as a general cellular mechanism for translocation of large cargoes across the nuclear envelope. Cargo is recruited, enveloped at the inner nuclear membrane (INM), and delivered by membrane fusion at the outer nuclear membrane. To understand the structural underpinning for this trafficking, we investigated nuclear egress of progeny herpesvirus capsids where capsid envelopment is mediated by two viral proteins, forming the nuclear eg...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cell.2015.11.029

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Biology
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
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Funding agency for:
Grange, M
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Funding agency for:
Grünewald, K
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Funding agency for:
Grünewald, K
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Grant:
060208/Z/00/Z; 093305/Z/10/Z; 090532/Z/09/Z; Strategic Award 091911
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Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
163
Issue:
7
Pages:
1692-1701
Publication date:
2015-12-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:ad28083d-3351-476e-8f50-432c1b3e7598
Source identifiers:
580985
Local pid:
pubs:580985
Language:
English

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