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Structural basis of vesicle formation at the inner nuclear membrane

Abstract:

Vesicular nucleo-cytoplasmic transport is becoming recognized as a general cellular mechanism for translocation of large cargoes across the nuclear envelope. Cargo is recruited, enveloped at the inner nuclear membrane (INM), and delivered by membrane fusion at the outer nuclear membrane. To understand the structural underpinning for this trafficking, we investigated nuclear egress of progeny herpesvirus capsids where capsid envelopment is mediated by two viral proteins, forming the nuclear eg...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Leverhulme Trust
Funding agency for:
Grünewald, K
Grant:
RPG-2012-519
More from this funder
Name:
Deutsche Forschungsgemeinschaft
Funding agency for:
Grünewald, K
Grant:
RPG-2012-519
More from this funder
Name:
Wellcome Trust
Funding agency for:
Grange, M
Grünewald, K
Grant:
RPG-2012-519
060208/Z/00/Z; 093305/Z/10/Z; 090532/Z/09/Z; Strategic Award 091911
More from this funder
Name:
European Union
Grant:
283570; 226716
Publisher:
Cell Press
Journal:
Cell More from this journal
Volume:
163
Issue:
7
Pages:
1692-1701
Publication date:
2015-12-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Language:
English
Pubs id:
pubs:580985
UUID:
uuid:ad28083d-3351-476e-8f50-432c1b3e7598
Local pid:
pubs:580985
Source identifiers:
580985
Deposit date:
2016-02-01

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