Journal article
Benefits of aldosterone receptor antagonism in chronic kidney disease: the BARACK-D RCT
- Abstract:
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Background
Chronic kidney disease affects around 10% of the global population and is associated with significant risk of progression to end-stage renal disease and vascular events. Aldosterone receptor antagonists such as spironolactone have shown prognostic benefits in patients with heart failure, but effects on patients with chronic kidney disease are uncertain.
Objectives
To determine the effect of low-dose spironolactone on mortality and card... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 5.2MB, Terms of use)
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- Publisher copy:
- 10.3310/pyft6977
Authors
+ National Institute for Health and Care Research
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- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- 12/01/52
- Programme:
- Health Technology Assessment programme
- Publisher:
- NIHR Journals Library
- Journal:
- Health Technology Assessment More from this journal
- Volume:
- 29
- Issue:
- 5
- Pages:
- 1-130
- Place of publication:
- England
- Publication date:
- 2025-03-01
- Acceptance date:
- 2025-03-28
- DOI:
- EISSN:
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2046-4924
- ISSN:
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1366-5278
- Pmid:
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40106397
- Language:
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English
- Pubs id:
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2095459
- Local pid:
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pubs:2095459
- Deposit date:
-
2025-06-10
- ARK identifier:
Terms of use
- Copyright holder:
- Hobbs et al.
- Copyright date:
- 2025
- Rights statement:
- © 2025 Hobbs et al. This work was produced by Hobbs et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This is an Open Access publication distributed under the terms of the Creative Commons Attribution CC BY 4.0 licence, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. See: https://creativecommons.org/licenses/by/4.0/. For attribution the title, original author(s), the publication source – NIHR Journals Library, and the DOI of the publication must be cited.
- Licence:
- CC Attribution (CC BY)
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