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Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

Abstract:

Synaptic-vesicle exocytosis is mediated by the vesicular Ca 2+ sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2). However, it is unclear how these interactions contribute to triggering membrane fusion. Using PC12 cells from Rattus norvegicus and artificial supported bilayers, we show that synaptotagmin-1 interacts with the polybasic linker region of syntaxin-1A independent of Ca 2+...

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Publisher copy:
10.1038/nsmb.2570

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Journal:
Nature Structural and Molecular Biology More from this journal
Volume:
20
Issue:
6
Pages:
679-686
Publication date:
2013-06-01
DOI:
EISSN:
1545-9985
ISSN:
1545-9993
Language:
English
Pubs id:
pubs:410095
UUID:
uuid:acfa1598-64ea-4adc-be2e-da9f42417a17
Local pid:
pubs:410095
Source identifiers:
410095
Deposit date:
2013-11-16

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