Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation

Journal article

Collectively, the presented data show that clinically applied fractionated low-dose irradiation can induce a delayed type I interferon response that occurs independently of interferon expression or STING signaling. These findings have implications for current efforts that aim to target the type I interferon response for cancer treatment.

Authors: Goedegebuure, RSA; Kleibeuker, EA; Buffa, FM; Castricum, KCM; Haider, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: BioMed Central
• Journal: Journal of Experimental & Clinical Cancer Research
• Volume: 40
• Issue: 1
• Pages: 161-161
• Article number: 161
• Publication date: 2021-05-08
• DOI: 10.1186/s13046-021-01962-2
• EISSN: 1756-9966
• ISSN: 1756-9966
• Language: English
• Keywords: Stimulator of interferon genes; Molecular biology; Sting; Innate immune system; Immunology; Medicine; Biology; Cancer research; Gene; Cancer; Gene expression; Interferon; Internal medicine; Genetics; Immune system