Journal article : Review
DNA–protein crosslink proteases in genome stability
- Abstract:
- Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are common and bulky DNA lesions that interfere with DNA replication, repair, transcription and recombination. Research in the past several years indicates that cells possess dedicated enzymes, known as DPC proteases, which digest the protein component of a DPC. Interestingly, DPC proteases also play a role in proteolysis beside DPC repair, such as in degrading excess histones during DNA replication or controlling DNA replication checkpoints. Here, we discuss the importance of DPC proteases in DNA replication, genome stability and their direct link to human diseases and cancer therapy.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.2MB, Terms of use)
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- Publisher copy:
- 10.1038/s42003-020-01539-3
Authors
- Publisher:
- Springer Nature
- Journal:
- Communications Biology More from this journal
- Volume:
- 4
- Issue:
- 1
- Article number:
- 11
- Publication date:
- 2021-01-04
- Acceptance date:
- 2020-12-01
- DOI:
- EISSN:
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2399-3642
- Pmid:
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33398053
- Language:
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English
- Keywords:
- Subtype:
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Review
- Pubs id:
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1152604
- Local pid:
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pubs:1152604
- Deposit date:
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2022-04-23
Terms of use
- Copyright holder:
- Ruggiano and Ramadan
- Copyright date:
- 2021
- Rights statement:
- © The Author(s) 2021. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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