Journal article

Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya

Abstract:: We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e antigen positive. It also correlated with a higher alanine aminotransferase (ALT) level (P = .03), raised aspartate transaminase-to-platelet ratio index (APRI) (P < .001), and higher elastography scores (P = .03).

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Downs, L. O., Okanda, D., Chirro, O., Zaharani, M., Safari, B., Aliyan, N., Andersson, M. I., Tanaka, Y., Etyang, A. O., Shimakawa, Y., Githinji, G., & Matthews, P. C. (2025). Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya. Open Forum Infectious Diseases, 12(3).

MLA Style

Downs, LO, et al. “Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.” Open Forum Infectious Diseases, vol. 12, no. 3, 2025.

Chicago Style

Downs, LO, D Okanda, O Chirro, et al. 2025. “Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya.” Open Forum Infectious Diseases 12 (3).
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Files:: Downs_et_al_2025_Hepatitis_B_Core-Related.pdf

(Preview, Version of record, pdf, 290.8KB, Terms of use)

Publisher copy:: 10.1093/ofid/ofaf125

Authors

+ Downs, LO More by this author

Institution:: University of Oxford
Role:: Author
ORCID:: 0000-0002-6088-4704

+ Okanda, D More by this author

Role:: Author

+ Chirro, O More by this author

Role:: Author
ORCID:: 0000-0002-1799-8503

+ Zaharani, M More by this author

Role:: Author

+ Safari, B More by this author

Role:: Author

More authors...

+ JSPS KAKENHI More from this funder

+ Francis Crick Institute More from this funder

+ Oxford Hospitals Charity More from this funder

+ Wellcome Doctoral Training Fellowship More from this funder

+ University College London Hospitals NIHR Biomedical Research Centre More from this funder

Publisher:: Oxford University Press
Journal:: Open Forum Infectious Diseases More from this journal
Volume:: 12
Issue:: 3
Article number:: ofaf125
Publication date:: 2025-03-06
Acceptance date:: 2025-03-03
DOI:: 10.1093/ofid/ofaf125
EISSN:: 2328-8957
ISSN:: 2328-8957

Language:: English
Keywords:: HBV

hepatitis B core-related antigen

liver disease

treatment

point-of-care diagnostics
Pubs id:: 2094542
Local pid:: pubs:2094542
Source identifiers:: 2786864
Deposit date:: 2025-03-20
ARK identifier:: ark:/29072/ora_ac86320c68504564bf5821ce615daa18

Terms of use

Copyright date:: 2025
Notes:: This work is related to the thesis Diagnosis, treatment and prevention of hepatitis B virus infection in Kilifi, Kenya.

Licence:: CC Attribution (CC BY)

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