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Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers

Abstract:

Actomyosin machinery endows cells with contractility at a single-cell level. However, within a monolayer, cells can be contractile or extensile based on the direction of pushing or pulling forces exerted by their neighbours or on the substrate. It has been shown that a monolayer of fibroblasts behaves as a contractile system while epithelial or neural progentior monolayers behave as an extensile system. Through a combination of cell culture experiments and in silico modelling, we reveal the m...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41563-021-00919-2

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Role:
Author
ORCID:
0000-0002-1116-4268
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Role:
Author
ORCID:
0000-0001-5963-3310
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Role:
Author
ORCID:
0000-0002-7483-8434
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Name:
Novo Nordisk Fonden (Novo Nordisk Foundation)
Publisher:
Nature Research
Journal:
Nature Materials More from this journal
Volume:
20
Issue:
8
Pages:
1156–1166
Publication date:
2021-02-18
Acceptance date:
2020-12-23
DOI:
EISSN:
1476-4660
ISSN:
1476-1122
Language:
English
Keywords:
Pubs id:
1162830
Local pid:
pubs:1162830
Deposit date:
2021-03-07

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