Journal article icon

Journal article

Consistent linkage of dominantly inherited osteogenesis imperfecta to the type I collagen loci: COL1A1 and COL1A2.

Abstract:

The segregation of COL1A1 and COL1A2, the two genes which encode the chains of type I collagen, was analyzed in 38 dominant osteogenesis imperfecta (OI) pedigrees by using polymorphic markers within or close to the genes. This was done in order to estimate the consistency of linkage of OI genes to these two loci. None of the 38 pedigrees showed evidence of recombination between the OI gene and both collagen loci, suggesting that the frequency of unlinked loci in the population must be low. Fr...

Expand abstract
Publication status:
Published

Actions


Authors


Expand authors...
Publisher:
University of Chicago Press
Journal:
American journal of human genetics
Volume:
46
Issue:
2
Pages:
293-307
Publication date:
1990-02-05
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:ac820672-4430-4a38-a6bb-1e6884b3941a
Source identifiers:
108615
Local pid:
pubs:108615

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP