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Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

Abstract:

Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-naïve children aged >5 years mainta...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Funding agency for:
Goulder, P
Grant:
RO1 AI46995
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Funding agency for:
Goulder, P
Grant:
RO1 AI46995
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Grant:
WT104748MA to P.G
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Translational Medicine Journal website
Volume:
8
Issue:
358
Pages:
pp. 358ra125
Publication date:
2016-09-01
Acceptance date:
2016-08-22
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pmid:
27683550
Source identifiers:
648082
Language:
English
Keywords:
Pubs id:
pubs:648082
UUID:
uuid:ac603e9b-00b1-4835-b5c9-32eaf482b09f
Local pid:
pubs:648082
Deposit date:
2016-10-10

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