Journal article icon

Journal article

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

Abstract:

Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-naïve children aged >5 years mainta...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Goulder, P
Grant:
RO1 AI46995
WT104748MA to P.G
More from this funder
Name:
National Institutes of Health
Grant:
RO1 AI46995 to P.G
RO1 AI46995
Funding agency for:
Goulder, P
Publisher:
American Association for the Advancement of Science
Journal:
Science Translational Medicine More from this journal
Volume:
8
Issue:
358
Pages:
pp. 358ra125
Publication date:
2016-09-01
Acceptance date:
2016-08-22
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Pmid:
27683550
Language:
English
Keywords:
Pubs id:
pubs:648082
UUID:
uuid:ac603e9b-00b1-4835-b5c9-32eaf482b09f
Local pid:
pubs:648082
Source identifiers:
648082
Deposit date:
2016-10-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP