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Subunit architecture of intact protein complexes from mass spectrometry and homology modeling.

Abstract:

Proteomic studies have yielded detailed lists of protein components. Relatively little is known, however, of interactions between proteins or of their spatial arrangement. To bridge this gap, we are developing a mass spectrometry approach based on intact protein complexes. By studying intact complexes, we show that we are able to not only determine the stoichiometry of all subunits present but also deduce interaction maps and topological arrangements of subunits. To construct an interaction n...

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Publication status:
Published

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Publisher copy:
10.1021/ar700218q

Authors


Taverner, T More by this author
Hernández, H More by this author
Ruotolo, BT More by this author
Matak-Vinković, D More by this author
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Journal:
Accounts of chemical research
Volume:
41
Issue:
5
Pages:
617-627
Publication date:
2008-05-05
DOI:
EISSN:
1520-4898
ISSN:
0001-4842
URN:
uuid:ac5dfa08-5329-4c14-8d29-1d993e50d6ea
Source identifiers:
59309
Local pid:
pubs:59309

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