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Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3.

Abstract:

The sinus node (or sinoatrial node [SAN]), the pacemaker of the heart, is a functionally and structurally heterogeneous tissue, which consists of a large "head" within the right caval vein myocardium and a "tail" along the terminal crest. Here, we investigated its cellular origin and mechanism of formation. Using genetic lineage analysis and explant assays, we identified T-box transcription factor Tbx18-expressing mesenchymal progenitors in the inflow tract region that differentiate into pace...

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Journal:
Circulation research More from this journal
Volume:
104
Issue:
3
Pages:
388-397
Publication date:
2009-02-01
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
Language:
English
Keywords:
Pubs id:
pubs:482165
UUID:
uuid:ac5ba0cc-70d9-446c-8e34-4e99a788ceb8
Local pid:
pubs:482165
Source identifiers:
482165
Deposit date:
2014-08-30

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