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A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Abstract:

Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippoc...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s42003-019-0537-9

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Author
ORCID:
0000-0003-1606-8643
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Role:
Author
ORCID:
0000-0002-3597-1531
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ORCID:
0000-0002-8564-5021
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Role:
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ORCID:
0000-0002-1115-4430
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Author
ORCID:
0000-0003-1942-5845
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Publisher:
Nature Research Publisher's website
Journal:
Communications Biology Journal website
Volume:
2
Article number:
285
Publication date:
2019-08-02
Acceptance date:
2019-05-14
DOI:
EISSN:
2399-3642
Pmid:
31396565

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