Journal article
Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo.
- Abstract:
-
Functional studies show that programming of CD8+ T cells occurs early after initial antigen encounter within as little as 2 hours. To define the molecular basis of these events, we transferred TCR transgenic T cells from F5 Rag-/- mice into naive recipients and stimulated them with recombinant vaccinia expressing the immunodominant influenza epitope NP366-374. Transcription in epitope-specific cytotoxic T lymphocytes (CTLs) was analyzed using Affymetrix 430 2.0 GeneChips and quantitative poly...
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- Publication status:
- Published
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- Publisher copy:
- 10.1182/blood-2006-03-011643
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Authors
Bibliographic Details
- Journal:
- Blood
- Volume:
- 109
- Issue:
- 3
- Pages:
- 1086-1094
- Publication date:
- 2007-02-01
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
33607
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:33607
- UUID:
-
uuid:ac4351ef-c237-4aa0-a60c-3a31ec18280d
- Local pid:
- pubs:33607
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2007
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