Journal article
DNA-guided DNA interference by a prokaryotic Argonaute.
- Abstract:
-
RNA interference is widely distributed in eukaryotes and has a variety of functions, including antiviral defence and gene regulation. All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide proteins of the Argonaute (Ago) family to complementary ssRNA targets: RNA-guided RNA interference. The role of prokaryotic Ago variants has remained elusive, although bioinformatics analysis has suggested their involvement in host defence. Here we demonstrate that Ago of t...
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- Publisher copy:
- 10.1038/nature12971
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Authors
Bibliographic Details
- Journal:
- Nature
- Volume:
- 507
- Issue:
- 7491
- Pages:
- 258-261
- Publication date:
- 2014-03-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:ac42b210-97f7-49f2-be37-553c581e4912
- Source identifiers:
-
449364
- Local pid:
- pubs:449364
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2014
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