- Abstract:
-
RNA interference is widely distributed in eukaryotes and has a variety of functions, including antiviral defence and gene regulation. All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide proteins of the Argonaute (Ago) family to complementary ssRNA targets: RNA-guided RNA interference. The role of prokaryotic Ago variants has remained elusive, although bioinformatics analysis has suggested their involvement in host defence. Here we demonstrate that Ago of t...
Expand abstract - Publisher copy:
- 10.1038/nature12971
-
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- Journal:
- Nature
- Volume:
- 507
- Issue:
- 7491
- Pages:
- 258-261
- Publication date:
- 2014-03-05
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- URN:
-
uuid:ac42b210-97f7-49f2-be37-553c581e4912
- Source identifiers:
-
449364
- Local pid:
- pubs:449364
- Language:
- English
- Keywords:
- Copyright date:
- 2014
Journal article
DNA-guided DNA interference by a prokaryotic Argonaute.
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