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DNA-guided DNA interference by a prokaryotic Argonaute.

Abstract:

RNA interference is widely distributed in eukaryotes and has a variety of functions, including antiviral defence and gene regulation. All RNA interference pathways use small single-stranded RNA (ssRNA) molecules that guide proteins of the Argonaute (Ago) family to complementary ssRNA targets: RNA-guided RNA interference. The role of prokaryotic Ago variants has remained elusive, although bioinformatics analysis has suggested their involvement in host defence. Here we demonstrate that Ago of t...

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Publisher copy:
10.1038/nature12971

Authors


Swarts, DC More by this author
Westra, ER More by this author
Janssen, JH More by this author
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Journal:
Nature
Volume:
507
Issue:
7491
Pages:
258-261
Publication date:
2014-03-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:ac42b210-97f7-49f2-be37-553c581e4912
Source identifiers:
449364
Local pid:
pubs:449364

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