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Synthesis of macrocyclic natural products by catalyst-controlled stereoselective ring-closing metathesis.

Abstract:

Many natural products contain a C = C double bond through which various other derivatives can be prepared; the stereochemical identity of the alkene can be critical to the biological activities of such molecules. Catalytic ring-closing metathesis (RCM) is a widely used method for the synthesis of large unsaturated rings; however, cyclizations often proceed without control of alkene stereochemistry. This shortcoming is particularly costly when the cyclization reaction is performed after a long...

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Publication status:
Published

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Publisher copy:
10.1038/nature10563

Authors


Jakubec, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Nature
Volume:
479
Issue:
7371
Pages:
88-93
Publication date:
2011-11-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:ac4110d8-931b-4e48-9cd0-9eab7b47015b
Source identifiers:
206131
Local pid:
pubs:206131

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