Journal article icon

Journal article

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Abstract:

The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair. Depletion of WRN induces widespread DNA double-strand breaks in MSI cells, leading to cell cycle arrest and/or apoptosis. However, the mechanism by which WRN protects MSI-associated cancers from double-strand breaks remains unclear. Here we show that TA-dinucleotide repeats are highly unstable in MSI cells a...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41586-020-2769-8

Authors


More by this author
Role:
Author
ORCID:
0000-0001-6136-5757
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0002-7460-2560
Expand authors...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Journal website
Volume:
586
Issue:
7828
Pages:
292-298
Publication date:
2020-09-30
Acceptance date:
2020-07-16
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Language:
English
Keywords:
Pubs id:
1136334
Local pid:
pubs:1136334
Deposit date:
2020-10-07

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP