Journal article
Repeat expansions confer WRN dependence in microsatellite-unstable cancers
- Abstract:
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The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair. Depletion of WRN induces widespread DNA double-strand breaks in MSI cells, leading to cell cycle arrest and/or apoptosis. However, the mechanism by which WRN protects MSI-associated cancers from double-strand breaks remains unclear. Here we show that TA-dinucleotide repeats are highly unstable in MSI cells a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, 602.9KB)
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- Publisher copy:
- 10.1038/s41586-020-2769-8
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Authors
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Journal website
- Volume:
- 586
- Issue:
- 7828
- Pages:
- 292-298
- Publication date:
- 2020-09-30
- Acceptance date:
- 2020-07-16
- DOI:
- EISSN:
-
1476-4687
- ISSN:
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0028-0836
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1136334
- Local pid:
- pubs:1136334
- Deposit date:
- 2020-10-07
Terms of use
- Copyright holder:
- US Government
- Copyright date:
- 2020
- Rights statement:
- © 2020. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41586-020-2769-8
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