Is a human CD8 T-cell vaccine possible, and if so, what would it take? Could a CD8+ T-cell vaccine prevent persistent HIV infection?

Journal article

Vaccines that stimulate CD8+ T cells could clear early virus infection or control ongoing infection and prevent disease. This could be valuable to combat human immunodeficiency virus type 1 (HIV-1) where it has not yet been possible to generate broadly reacting neutralizing antibodies with a vaccine. However, HIV-1 vaccines aimed at stimulating CD8+ T cells have had no success. In contrast, a cytomegalovirus vectored simian immunodeficiency virus (SIV) vaccine enabled clearance of early SIV infection. This may open the door to the design of an effective HIV vaccine.

Authors: McMichael, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Cold Spring Harbor Laboratory Press
• Journal: Cold Spring Harbor Perspectives in Biology
• Publication date: 2017-12-01
• DOI: 10.1101/cshperspect.a029124
• ISSN: 1943-0264
• Pmid: 29254977
• Language: English
• Keywords: Journal Article