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Is a human CD8 T-cell vaccine possible, and if so, what would it take? Could a CD8+ T-cell vaccine prevent persistent HIV infection?

Abstract:

Vaccines that stimulate CD8+ T cells could clear early virus infection or control ongoing infection and prevent disease. This could be valuable to combat human immunodeficiency virus type 1 (HIV-1) where it has not yet been possible to generate broadly reacting neutralizing antibodies with a vaccine. However, HIV-1 vaccines aimed at stimulating CD8+ T cells have had no success. In contrast, a cytomegalovirus vectored simian immunodeficiency virus (SIV) vaccine enabled clearance of early SIV i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/cshperspect.a029124

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Publisher:
Cold Spring Harbor Laboratory Press Publisher's website
Journal:
Cold Spring Harbor Perspectives in Biology Journal website
Publication date:
2017-12-05
DOI:
ISSN:
1943-0264
Pubs id:
pubs:813203
URN:
uri:ac2e4cd6-9f31-4ae2-b034-90a3cd496deb
UUID:
uuid:ac2e4cd6-9f31-4ae2-b034-90a3cd496deb
Local pid:
pubs:813203
Language:
English
Keywords:

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