Not Just N e N e -More: New Applications for SMC from Ecology to Phylogenies

Journal article : Review

Genomes contain the mutational footprint of an organism’s evolutionary history, shaped by diverse forces including ecological factors, selective pressures, and life history traits. The sequentially Markovian coalescent (SMC) is a versatile and tractable model for the genetic genealogy of a sample of genomes, which captures this shared history. Methods that utilize the SMC, such as PSMC and MSMC, have been widely used in evolution and ecology to infer demographic histories. However, these methods ignore common biological features, such as gene flow events and structural variation. Recently, there have been several advancements that widen the applicability of SMC-based methods: inclusion of an isolation with migration model, integration with the multi-species coalescent, incorporation of ecological life history traits (such as selfing and dormancy), and many computational advances in applying these models to data. We give an overview of the SMC model and its various recent extensions, discuss examples of biological discoveries through SMC-based inference, and comment on the assumptions, benefits and drawbacks of various methods.

Authors: Peede, D; Cousins, T; Durvasula, A; Ignatieva, A; Kovacs, TGL

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Oxford University Press
• Journal: Genome Biology and Evolution
• Volume: 18
• Issue: 1
• Pages: evaf229
• Article number: evaf229
• Publication date: 2025-11-28
• Acceptance date: 2025-11-12
• DOI: 10.1093/gbe/evaf229
• EISSN: 1759-6653
• ISSN: 1759-6653
• Language: English
• Keywords: sequentially Markovian coalescent; gene flow; conservation biology; ARG reconstruction; demographic inference
• Subtype: Review