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Combining tandem mass spectrometry with ion mobility separation to determine the architecture of polydisperse proteins

Abstract:

Polydispersity presents a considerable challenge for the detailed molecular characterisation of many proteins. This is because in most biophysical and structural biology approaches the molecules in solution are ensemble-averaged, obscuring differences between individual proteins or conformational states. Mass spectrometry is however inherently dispersive, allowing the specific interrogation of molecules with distinct mass-to-charge ratios. Here, we exploit this intrinsic benefit to develop a ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ijms.2014.09.007

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Publisher:
Elsevier
Journal:
International Journal of Mass Spectrometry More from this journal
Volume:
377
Pages:
663–671
Publication date:
2015-02-01
DOI:
ISSN:
1387-3806
Language:
English
Keywords:
UUID:
uuid:ac1fa881-4748-44d6-8241-8c5d874435c6
Local pid:
pubs:489263
Source identifiers:
489263
Deposit date:
2014-11-16

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