Editorial: Exosomes: Message in a vesicle

Journal article

Exosomes are a class of extracellular vesicles (EVs) comprising a heterogenous population of biological nano-vesicles enclosed by a lipid bilayer All eukaryotic cells produce and release EVs into the surrounding extracellular space, including exosomes. Because the term 'exosome' refers to a specific biogenesis pathway that produces some EVs EVs carry various cargoes including nucleic acids, such as miRNA and mRNA, proteins, and lipids. Although EVs originally was thought to be a disposal mechanism of unwanted biomaterials, it became evident in recent years that they play a crucial role in intricate signaling pathways and intercellular communication (Figure Collaborative efforts across the globe have helped elucidate the pathway of EV biogenesis and their involvement in several human diseases. This Research Topic is a collection of original articles, review articles, and one brief research report that highlight current knowledge on different isolation and characterization methods for EVs, their roles in intercellular communications, therapeutic applications, potential as a source of biomarkers, and their use as a vehicle for drug delivery. In total, the Research Topic contains sixteen papers by experts in the corresponding fields describing and discussing enthralling breakthroughs over the past several years in the EV research field.

Authors: Dutta, S; Nimse, SB; Van Keuren-Jensen, K; Bitan, G

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Frontiers Media
• Journal: Frontiers in Pharmacology
• Volume: 13
• Pages: 1018928-1018928
• Article number: 1018928
• Publication date: 2022-09-08
• DOI: 10.3389/fphar.2022.1018928
• EISSN: 1663-9812
• ISSN: 1663-9812
• Language: English
• Keywords: Membrane; Extracellular vesicles; Biology; Microvesicles; microRNA; Gene; Vesicle; Chemistry; Computational biology; Cell biology; Medicine; Biochemistry