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Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.

Abstract:

Using biochemical, epifluorescence and electron microscopic techniques in a U937 model system, we investigated the effect of anti-allergic drugs di-sodium cromoglycate and sodium nedocromil on the trafficking and release of the anti-inflammatory protein Annexin-A1 (Anx-A1) when this was triggered by glucocorticoid (GC) treatment. GCs alone produced a rapid (within 5min) concentration-dependent activation of PKCalpha/beta (Protein Kinase C; EC 2.7.11.13) and phosphorylation of Anx-A1 on Ser(27...

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Publication status:
Published

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Publisher copy:
10.1016/j.bcp.2009.03.010

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Journal:
Biochemical pharmacology
Volume:
77
Issue:
12
Pages:
1814-1826
Publication date:
2009-06-05
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
URN:
uuid:ac0ccb80-9ace-403d-a83d-01d8993b5b37
Source identifiers:
311934
Local pid:
pubs:311934

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