Journal article icon

Journal article

Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation

Abstract:

Spinocerebellar ataxia type 14 (SCA14) is a subtype of the autosomal dominant cerebellar ataxias that is characterized by slowly progressive cerebellar dysfunction and neurodegeneration. SCA14 is caused by mutations in the PRKCG gene, encoding protein kinase C gamma (PKCγ). Despite the identification of 40 distinct disease-causing mutations in PRKCG, the pathological mechanisms underlying SCA14 remain poorly understood. Here we report the molecular neuropathology of SCA14 in post-mortem cereb...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1186/s40478-018-0600-7

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Vowles, J
More from this funder
Funding agency for:
Watson, L
More from this funder
Funding agency for:
Cowley, S
More from this funder
Funding agency for:
Cowley, S
Expand funders...
Publisher:
BMC Publisher's website
Journal:
Acta Neuropathologica Communications Journal website
Volume:
99
Issue:
6
Publication date:
2018-09-24
Acceptance date:
2018-09-14
DOI:
EISSN:
2051-5960
Pubs id:
pubs:919577
URN:
uri:ac086ebc-b9e9-47b2-9ec2-6832b147c726
UUID:
uuid:ac086ebc-b9e9-47b2-9ec2-6832b147c726
Local pid:
pubs:919577

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP