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ARF induction in response to DNA strand breaks is regulated by PARP1

Abstract:

The ARF tumour suppressor protein, the gene of which is frequently mutated in many human cancers, plays an important role in the cellular stress response by orchestrating up-regulation of p53 protein and consequently promoting cell-cycle delay. Although p53 protein function has been clearly linked to the cellular DNA damage response, the role of ARF protein in this process is unclear. Here, we report that arf gene transcription is induced by DNA strand breaks (SBs) and that ARF prote...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gkt1185

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Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Medical Research Council More from this funder
Cancer Research UK More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic Acids Research Journal website
Pages:
1–10
Publication date:
2013-11-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:ac036ae6-828a-4ec5-a31e-bbfe249ae216
Local pid:
ora:8063
Language:
English
Keywords:
Subjects:

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