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Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity.

Abstract:

Human CMV (HCMV) has evolved several strategies to evade the immune system of the infected host. Here, we investigated the role of the HCMV-encoded protein UL40 in the modulation of NK cell lysis. UL40 carries in its leader sequence a nonameric peptide similar to that found in many HLA class I molecules leader sequences. This peptide up-regulates the expression of HLA-E, the ligand for the NK cell inhibitory receptor CD94/NKG2A. The UL40-encoded HLA-E-binding peptide was present in all HCMV c...

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Publication status:
Published

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Journal:
European journal of immunology More from this journal
Volume:
31
Issue:
10
Pages:
2926-2935
Publication date:
2001-10-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Language:
English
Keywords:
Pubs id:
pubs:382786
UUID:
uuid:abdfe42f-a5d1-4372-8132-09c4f8edaf94
Local pid:
pubs:382786
Source identifiers:
382786
Deposit date:
2013-11-16

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