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Journal article

Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis

Abstract:

Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), can be suppressed in its early stages but eventually becomes clinically progressive and unresponsive to therapy. Here, we investigate whether the therapeutic resistance of progressive MS can be attributed to chronic immune cell accumulation behind the blood-brain barrier (BBB).
Methods We systematically track CNS-homing immune cells in the peripheral blood ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.medj.2021.01.006

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Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Neurosciences
Role:
Author
Publisher:
Elsevier
Journal:
Med More from this journal
Volume:
2
Issue:
3
Pages:
296-312.e8
Publication date:
2021-02-16
Acceptance date:
2021-01-26
DOI:
ISSN:
2666-6340
Language:
English
Keywords:
Pubs id:
1166681
Local pid:
pubs:1166681
Deposit date:
2021-03-09

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