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Journal article

A novel oxygen-sensitive potassium current in rat carotid body type I cells.

Abstract:

1. Hypoxic stimuli depolarize carotid body type I cells causing voltage-gated calcium influx. This study investigates the cause of this membrane depolarization. Isolated type I cells from neonatal (11-16 day) rat carotid bodies were used in the experiments. 2. Tetraethylammonium (TEA; 10 mM), 1 and 5 mM 4-aminopyridine (4-AP) and 20 nM charybdotoxin all failed to evoke a significant rise in [Ca2+]i. Similarly, in perforated patch whole-cell recordings, a combination of 10 mM TEA and 5 mM 4-AP...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of physiology
Volume:
498 ( Pt 3)
Issue:
3
Pages:
649-662
Publication date:
1997-02-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
312280
Language:
English
Keywords:
Pubs id:
pubs:312280
UUID:
uuid:abbc77f1-0f30-4aee-99c3-b49df5bab8c2
Local pid:
pubs:312280
Deposit date:
2013-11-16

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