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Association of low‐activity ALDH2 and alcohol consumption with risk of esophageal cancer in Chinese adults: A population‐based cohort study

Abstract:

Existing evidence remains inconclusive as to how the association between inactive ALDH2 and esophageal cancer (EC)depends on alcohol consumption. The study is based on the China Kadoorie Biobank cohort, with 10 years follow-up of 0.5million adults aged 30–79 years. ALDH2 activity was assessed by both self-reported flushing response and Glu504Lys(rs671 G>A) polymorphism. Among both male and female participants who consumed alcohol less than weekly(n569,519; 211 EC cases), low active or inac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/ijc.31566

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Nuffield Department of Population Health; Clinical Trial Service Unit
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
088158/Z/09/Z
104085/Z/14/Z
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Name:
Kadoorie Charitable Foundation
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Name:
Chinese Ministry of Science and Technology
More from this funder
Name:
National Key Research and Development Program of China
More from this funder
Name:
National Natural Science Foundation of China
Publisher:
Wiley
Journal:
International Journal of Cancer More from this journal
Volume:
143
Issue:
7
Pages:
1652-1661
Publication date:
2018-06-11
Acceptance date:
2018-04-23
DOI:
EISSN:
1097-0215
ISSN:
0020-7136
Keywords:
Pubs id:
pubs:844226
UUID:
uuid:abbb5fd2-dd3f-4b53-ada2-db9c3742f512
Local pid:
pubs:844226
Deposit date:
2018-04-25

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