Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial.

Journal article

BACKGROUND: In the UK, chemotherapy is the standard treatment for inoperable, locally advanced, non-metastatic pancreatic cancer. Chemoradiotherapy is also an acceptable treatment option, for which gemcitabine, fluorouracil, or capecitabine can be used as concurrent chemotherapy agents. We aimed to assess the activity, safety, and feasibility of both gemcitabine-based and capecitabine-based chemoradiotherapy after induction chemotherapy for patients with locally advanced pancreatic cancer. ME...

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Authors: Mukherjee, S; Hurt, C; Bridgewater, J; Falk, S; Cummins, S

• Publication status: Published
• Journal: Lancet. Oncology
• Volume: 14
• Issue: 4
• Pages: 317-326
• Publication date: 2013-04-01
• DOI: 10.1016/s1470-2045(13)70021-4
• EISSN: 1474-5488
• ISSN: 1470-2045
• Language: English
• Keywords: Disease-Free Survival; Treatment Outcome; Deoxycytidine; Pancreatic Neoplasms; Aged; Humans; Adult; Female; Drug-Related Side Effects and Adverse Reactions; Male; Fluorouracil; Kaplan-Meier Estimate; Antineoplastic Agents; Middle Aged