Journal article icon

Journal article

ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

Abstract:

ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and the change in expression is determined by the size of the TR, producing skewed allelic expression. This reveals the characteristics of the affected genes, explains the variable p...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.cell.2010.09.023

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
Garrick, D More by this author
Expand authors...
Journal:
Cell
Volume:
143
Issue:
3
Pages:
367-378
Publication date:
2010-10-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:aba489cc-7180-492a-9321-641e4e88e52d
Source identifiers:
93163
Local pid:
pubs:93163

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP