Host-adaptive antigenic variation in Bunyaviruses.

Journal article

Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.

Authors: James, W; Millican, D

• Publication status: Published
• Journal: Journal of general virology
• Volume: 67 ( Pt 12)
• Issue: 12
• Pages: 2803-2806
• Publication date: 1986-12-01
• DOI: 10.1099/0022-1317-67-12-2803
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English
• Keywords: Virus Replication; Antibodies, Viral; Animals; Antibodies, Monoclonal; Epitopes; Bunyamwera virus; Bunyaviridae; Neutralization Tests; Genes, Viral; Viral Envelope Proteins; Antigens, Viral; Cell Line; Aedes; Plaque Assay; Cercopithecus aethiops; Mutation