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Forces acting on codon bias in malaria parasites

Abstract:

Malaria parasite genomes have a range of codon biases, with Plasmodium falciparum one of the most AT-biased genomes known. We examined the make up of synonymous coding sites and stop codons in the core genomes of representative malaria parasites, showing first that local DNA context influences codon bias similarly across P. falciparum, P. vivax and P. berghei, with suppression of CpG dinucleotides and enhancement of CpC dinucleotides, both within and aross codons. Intense asexual phase gene e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-34404-9

Authors


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Role:
Author
ORCID:
0000-0002-6574-310X
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-5134-7165
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Name:
Wellcome Trust
Grant:
089275/Z/09/Z
Publisher:
Springer Nature
Journal:
Scientific Reports More from this journal
Volume:
8
Issue:
1
Article number:
15984
Publication date:
2018-10-29
Acceptance date:
2018-10-16
DOI:
EISSN:
2045-2322
Pmid:
30374097
Language:
English
Keywords:
Pubs id:
pubs:935901
UUID:
uuid:ab919a93-0917-4859-b3dd-0dd01619c7c5
Local pid:
pubs:935901
Source identifiers:
935901
Deposit date:
2019-05-20

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