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DNA Replication and associated repair pathways are involved in the mutagenesis of methylated cytosine

Abstract:

Transitions of cytosine to thymine in CpG dinucleotides are the most frequent type of mutations observed in cancer. This increased mutability is commonly explained by the presence of 5-methylcytosine (5mC) and its spontaneous hydrolytic deamination into thymine. Here, we describe observations that question whether spontaneous deamination alone causes the elevated mutagenicity of 5mC. Tumours with somatic mutations in DNA mismatch-repair genes or in the proofreading domain of DNA polymerase ε ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.dnarep.2017.11.005

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/F500394/1
More from this funder
Name:
Biotechnology and Biological Sciences Research Council
Grant:
B/M001873/1
Publisher:
Elsevier
Journal:
DNA Repair More from this journal
Volume:
62
Pages:
1-7
Publication date:
2017-11-24
Acceptance date:
2017-11-21
DOI:
ISSN:
1568-7856
Keywords:
Pubs id:
pubs:798389
UUID:
uuid:ab6b6334-d70b-4b98-a9d7-95da761e011c
Local pid:
pubs:798389
Source identifiers:
798389
Deposit date:
2017-11-28

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