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Journal article

Precursor structure, expression, and tissue distribution of human guanylin.

Abstract:

Heat-stable enterotoxins (STa) are small, cysteine-rich peptides secreted by Escherichia coli that are able to induce diarrhea through the stimulation of an intestine-specific receptor-guanylyl cyclase known as STaR. A 15-amino acid peptide, guanylin, was recently purified from rat jejunum and proposed to be a potential endogenous activator of this receptor. We describe here the cloning and characterization of human and mouse cDNAs encoding precursor proteins of 115 and 116 amino acids, respe...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.89.19.9089

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Medicine Division, Clinical Medicine
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
89
Issue:
19
Pages:
9089-9093
Publication date:
1992-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:ab44f043-59c0-484f-a189-df91648afba5
Source identifiers:
66435
Local pid:
pubs:66435

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