Good laboratory practice: preventing introduction of bias at the bench.

Journal article

BACKGROUND AND PURPOSE: As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review- Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy. CONCLUSIONS: Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

Authors: Macleod, MR; Fisher, M; O'Collins, V; Sena, E; Dirnagl, U

• Publication status: Published
• Journal: Stroke; a journal of cerebral circulation
• Volume: 40
• Issue: 3
• Pages: e50-e52
• Publication date: 2009-03-01
• DOI: 10.1161/strokeaha.108.525386
• EISSN: 1524-4628
• ISSN: 0039-2499
• Language: English
• Keywords: Sample Size; Conflict of Interest; Research Design; Random Allocation; Treatment Outcome; Research Support as Topic; Humans; Drug Industry; Disease Models, Animal; Stroke; Animals; Bias (Epidemiology)