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Suppression of airway inflammation by a natural acute infection of the intestinal epithelium.

Abstract:

Although chronic intestinal helminth infections may suppress allergen-induced airway pathology by inducing a combination of modified T-helper (Th) 2 and immunosuppressive cytokines, a similar capacity of natural acute intestinal infections has remained untested, despite their global prevalence. Here, we show that allergic airway phenotypes including eosinophilia, eotaxin mRNA, and Th2 cytokines are significantly suppressed in animals that were infected by and that have cleared the intestinal ...

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Publisher copy:
10.1038/mi.2008.83

Authors


Gibbons, DL More by this author
Copestake, SL More by this author
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Journal:
Mucosal immunology
Volume:
2
Issue:
2
Pages:
144-155
Publication date:
2009-03-05
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
URN:
uuid:ab34727e-bad5-4e23-a8ed-4390f4975771
Source identifiers:
315665
Local pid:
pubs:315665

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