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When is a hydrophobic gate not a hydrophobic gate?

Abstract:

The flux of ions through a channel is most commonly regulated by changes that result in steric occlusion of its pore. However, ion permeation can also be prevented by formation of a desolvation barrier created by hydrophobic residues that line the pore. As a result of relatively minor structural changes, confined hydrophobic regions in channels may undergo transitions between wet and dry states to gate the pore closed without physical constriction of the permeation pathway. This concept is...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1085/jgp.202213210

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
ORCID:
0000-0002-4250-558X
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Lady Margaret Hall
Role:
Author
ORCID:
0000-0001-5100-8836
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-8996-2000
Publisher:
Rockefeller University Press
Journal:
Journal of General Physiology More from this journal
Volume:
154
Issue:
11
Article number:
e202213210
Publication date:
2022-10-26
Acceptance date:
2022-10-06
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
Pmid:
36287215
Language:
English
Keywords:
Pubs id:
1287998
Local pid:
pubs:1287998
Deposit date:
2022-11-30

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