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The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells

Abstract:

Human embryonic stem (hES) cells have enormous potential for clinical applications. However, one major challenge is to achieve high cell recovery rate after cryopreservation. Understanding how the conventional cryopreservation protocol fails to protect the cells is a prerequisite for developing efficient and successful cryopreservation methods for hES cell lines and banks. We investigated how the stimuli from cryopreservation result in apoptosis, which causes ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/btpr.368

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Brasenose College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Name:
BB/D014824/1/Biotechnology and Biological Sciences Research Council
More from this funder
Name:
BBS/B/03599/Biotechnology and Biological Sciences Research Council
More from this funder
Name:
BB/D014751/1/Biotechnology and Biological Sciences Research Council
Publisher:
Wiley
Journal:
Biotechnology Progress More from this journal
Volume:
26
Issue:
3
Pages:
827-837
Publication date:
2010-01-13
DOI:
EISSN:
1520-6033
ISSN:
8756-7938
Pmid:
20077485
Language:
English
Keywords:
Pubs id:
pubs:45936
UUID:
uuid:ab2d0064-e084-418c-90f2-dfcdf8ef6f33
Local pid:
pubs:45936
Source identifiers:
45936
Deposit date:
2017-11-12

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