Role of ITAM signaling module in signal integration

Journal article

Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional...

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Authors: Bezbradica, J; Medzhitov, R

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier Publisher's website
• Journal: Current Opinion in Immunology Journal website
• Issue: 1
• Publication date: 2012-01-11
• Acceptance date: 2011-12-21
• DOI: 10.1016/j.coi.2011.12.010
• EISSN: 1879-0372
• ISSN: 0952-7915
• Pmid: 22240121
• Language: English
• Keywords: SBTMR