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Role of ITAM signaling module in signal integration

Abstract:

Diverse cell types use a small number of evolutionarily conserved signaling modules to integrate external cues and elicit distinct functions. A question thus arises as to how does a receptor, which contains a single signaling module, produce distinct outcomes to diverse signals, particularly if such module is shared amongst a family of receptors? Emerging data suggest that many immunoreceptors, all of which use a conserved ITAM-module for their signaling, can couple with members of additional...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.coi.2011.12.010

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
ORCID:
0000-0003-1441-1727
Publisher:
Elsevier
Journal:
Current Opinion in Immunology More from this journal
Issue:
1
Publication date:
2012-01-11
Acceptance date:
2011-12-21
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
Pmid:
22240121
Language:
English
Keywords:
Pubs id:
pubs:627582
UUID:
uuid:ab294495-97c9-4cc5-9da2-7b409fbb5345
Local pid:
pubs:627582
Source identifiers:
627582
Deposit date:
2018-03-05

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