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Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA.

Abstract:

Genetic evidence indicates that Drosophila defense against Gram-positive bacteria is mediated by two putative pattern recognition receptors acting upstream of Toll, namely Gram-negative binding protein 1 (GNBP1) and peptidoglycan recognition protein SA (PGRP-SA). Until now however, the molecular recognition proceedings for sensing of Gram-positive pathogens were not known. In the present, we report the physical interaction between GNBP1 and PGRP-SA using recombinant proteins. GNBP1 was able t...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601363

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Journal:
EMBO journal More from this journal
Volume:
25
Issue:
20
Pages:
5005-5014
Publication date:
2006-10-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Language:
English
Keywords:
Pubs id:
pubs:16955
UUID:
uuid:ab05230d-baf1-4d80-b73b-1774e2bd8b18
Local pid:
pubs:16955
Source identifiers:
16955
Deposit date:
2012-12-19

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