Journal article

DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

Abstract:: Quick and clean: A method for Pd-catalyzed Suzuki-Miyaura cross-coupling to iododeoxyuridine (IdU) in DNA is described. Key to the reactivity is the choice of the ligand and the buffer. A covalent [Pd]-DNA intermediate was isolated and characterized. Photocrosslinking probes were generated to trap proteins that bind to epigenetic DNA modifications.

Publication status:: Published

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APA Style

Lercher, L., McGouran, J., Kessler, B., Schofield, C., & Davis, B. (2013). DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes. Angewandte Chemie (International Ed. in English), 52(40), 10553–10558.

MLA Style

Lercher, L., et al. “DNA Modification under Mild Conditions by Suzuki-Miyaura Cross-Coupling for the Generation of Functional Probes.” Angewandte Chemie (International Ed. in English), vol. 52, no. 40, 2013, pp. 10553–58.

Chicago Style

Lercher, L, J McGouran, B Kessler, C Schofield, and B Davis. 2013. “DNA Modification under Mild Conditions by Suzuki-Miyaura Cross-Coupling for the Generation of Functional Probes.” Angewandte Chemie (International Ed. in English) 52 (40): 10553–58.
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Publisher copy:: 10.1002/anie.201304038

Authors

+ Lercher, L More by this author

Role:: Author

+ McGouran, J More by this author

Role:: Author

+ Kessler, B More by this author

Role:: Author

+ Schofield, C More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Davis, B More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

Journal:: Angewandte Chemie (International ed. in English) More from this journal
Volume:: 52
Issue:: 40
Pages:: 10553-10558
Publication date:: 2013-09-01
DOI:: 10.1002/anie.201304038
EISSN:: 1521-3773
ISSN:: 1433-7851

Language:: English
Keywords:: DNA

Palladium

Photoaffinity Labels

Idoxuridine

Oligonucleotides

Catalysis

Molecular Probes
Pubs id:: pubs:418412
UUID:: uuid:aaf45d95-ea81-40c5-a6d0-b4809c55ea6d
Local pid:: pubs:418412
Source identifiers:: 418412
Deposit date:: 2013-11-16

Terms of use

Copyright date:: 2013

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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