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Mutations in the insulin-like factor 3 receptor are associated with osteoporosis.

Abstract:

INTRODUCTION: Insulin-like factor 3 (INSL3) is produced primarily by testicular Leydig cells. It acts by binding to its specific G protein-coupled receptor RXFP2 (relaxin family peptide 2) and is involved in testicular descent during fetal development. The physiological role of INSL3 in adults is not known, although substantial INSL3 circulating levels are present. The aim of this study was to verify whether reduced INSL3 activity could cause or contribute to some signs of hypogonadism, such...

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Publisher copy:
10.1359/jbmr.080204

Authors


Journal:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research More from this journal
Volume:
23
Issue:
5
Pages:
683-693
Publication date:
2008-05-01
DOI:
EISSN:
1523-4681
ISSN:
0884-0431
Language:
English
Keywords:
Pubs id:
pubs:237678
UUID:
uuid:aac3ab60-d72c-427e-aea9-ad69e7061f9f
Local pid:
pubs:237678
Source identifiers:
237678
Deposit date:
2012-12-19

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