Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts

Westbury, LD; Harvey, NC; Beaudart, C; Bruyère, O; Cauley, JA; Cawthon, P; Cruz-Jentoft, AJ; Curtis, EM; Ensrud, K; Fielding, RA; Johansson, H; Kanis, JA; Karlsson, MK; Lane, NE; Lengelé, L; Lorentzon, M; McCloskey, E; Mellström, D; Newman, AB; Ohlsson, C; Orwoll, E; Reginster, J; Ribom, E; Rosengren, BE; Cooper, C

Journal article

Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts

Abstract:: Background: Low grip strength and gait speed are associated with mortality. However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited. Aim: We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors. Methods: Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4–6 m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell’s Concordance Index (C-index). Results: Mean (SD) age of participants (n = 8362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3 years. Grip strength (hazard ratio (95% CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index (95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed. Conclusions: Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Westbury, L. D., Harvey, N. C., Beaudart, C., Bruyère, O., Cauley, J. A., Cawthon, P., Cruz-Jentoft, A. J., Curtis, E. M., Ensrud, K., Fielding, R. A., Johansson, H., Kanis, J. A., Karlsson, M. K., Lane, N. E., Lengelé, L., Lorentzon, M., McCloskey, E., Mellström, D., Newman, A. B., … Cooper, C. (2024). Predictive value of sarcopenia components for all-cause mortality: findings from population-based cohorts. Aging Clinical and Experimental Research, 36(1).

MLA Style

Westbury, L. D., et al. “Predictive Value of Sarcopenia Components for All-Cause Mortality: Findings from Population-Based Cohorts.” Aging Clinical and Experimental Research, vol. 36, no. 1, Springer, 2024.

Chicago Style

Westbury, LD, NC Harvey, C Beaudart, O Bruyère, JA Cauley, P Cawthon, AJ Cruz-Jentoft, et al. 2024. “Predictive Value of Sarcopenia Components for All-Cause Mortality: Findings from Population-Based Cohorts.” Aging Clinical and Experimental Research 36 (1).
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