Journal article
Redefining clinical practice through spatial profiling: a revolution in tissue analysis
- Abstract:
- Spatial biology, which combines molecular biology and advanced imaging, enhances our understanding of tissue cellular organisation. Despite its potential, spatial omics encounters challenges related to data complexity, computational requirements and standardisation of analysis. In clinical applications, spatial omics has the potential to revolutionise biomarker discovery, disease stratification and personalised treatments. It can identify disease-specific cell patterns, and could help risk stratify patients for clinical trials and disease-appropriate therapies. Although there are challenges in adopting it in clinical practice, spatial omics has the potential to significantly enhance patient outcomes. In this paper, we discuss the recent evolution of spatial biology, and its potential for improving our tissue level understanding and treatment of disease, to help advance precision and effectiveness in healthcare interventions.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 326.7KB, Terms of use)
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- Publisher copy:
- 10.1308/rcsann.2023.0091
Authors
+ Wellcome Trust
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- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 090532/Z/09/Z
+ Cancer Research UK
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- Funder identifier:
- https://ror.org/054225q67
- Grant:
- DRCNPG-Jun22\100002
- A26825 and A28223
- Publisher:
- Royal College of Surgeons of England
- Journal:
- Annals of The Royal College of Surgeons of England More from this journal
- Volume:
- 106
- Issue:
- 4
- Pages:
- 305-312
- Place of publication:
- England
- Publication date:
- 2024-04-01
- Acceptance date:
- 2023-10-25
- DOI:
- EISSN:
-
1478-7083
- ISSN:
-
0035-8843
- Pmid:
-
38555868
- Language:
-
English
- Keywords:
- Pubs id:
-
1987988
- Local pid:
-
pubs:1987988
- Deposit date:
-
2025-04-07
- ARK identifier:
Terms of use
- Copyright holder:
- Mulholland, EJ and Leedham, SJ
- Copyright date:
- 2024
- Rights statement:
- © 2024, The Authors. Open Access. This is an open-access articledistributed under the terms of theAttribution-NonCommercial-NoDerivs 4.0 InternationalLicense, which enables reusers to copy and distribute thematerial in any medium or format in unadapted formonly, for noncommercial purposes only, provided theoriginal work is properly attributed. You may not use thematerial for commercial purposes. If you remix,transform, or build upon the material, you may notdistribute the modified material.
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